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Octreotide is a synthetic somatostatin analogue with several palliative care indications, including management of ascites, bowel obstruction, diarrhoea, fistulae and tumour secretions. We report a case in which parotid swelling occurred after octreotide, suggesting it may have been a causative factor in a salivary duct calculus.
Somatostatin is an inhibitory hormone which reduces hormone release including ACTH and growth hormone and inhibits glucagon, insulin and other gastric and pancreatic peptides. It reduces gastrointestinal motility and secretions, portal and splanchnic blood flow and increases intestinal absorption of water and electrolytes. In addition, it is an inhibitory neurotransmitter, with an effect on cell proliferation, inflammation and pain.1
Formation of biliary calculi with somatostatin analogues is well recognised in both acromegaly …
Contributors KLJ is the sole author of the work.
Funding The author has not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient consent for publication Not required.
Provenance and peer review Not commissioned; internally peer reviewed.