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Contributors MAN, MHS and ABJ made substantial contribution to the concept, design, analysis, interpretation of data and drafted the article. MAN, MHS, TB, EB, AL, SA, HW, PA and ABJ revised the article critically for important intellectual content and approved the version to be published.
Funding This work was supported by the Danish Cancer Society and the Danish foundation TrygFonden.
Competing interests None declared.
Patient consent for publication Not required.
Ethics approval According to the Central Denmark Region Committee on Health Research Ethics, this study does not need any ethics approval (j. no. 35/2013). The study was approved by the Danish Data Protection Agency (j. no. 1-16-02-367-14) and registered with ClinicalTrials.gov (NCT01944813).
Provenance and peer review Not commissioned; externally peer reviewed.