Background Studies that have evaluated the use of intravenous vitamin C in adults with
sepsis who were receiving vasopressor therapy in the intensive care unit (ICU) have shown …

Purpose To estimate the incidence, severity, duration and consequences of bleeding during
critical illness, and to test the performance characteristics of a new bleeding assessment …

Objective: Protocolized sedation (PS) and daily sedative interruption (DI) in critically ill
patients have both been shown to shorten the durations of mechanical ventilation (MV) and …

Purpose To describe pre-ICU frailty in critically ill patients using the Clinical Frailty Scale
(CFS). Methods We included patients≥ 18 years admitted to 2 ICUs in Hamilton, Canada …

Background: Dying in the complex, efficiency-driven environment of the intensive care unit
can be dehumanizing for the patient and have profound, long-lasting consequences for all …

Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
pandemic has affected the hospital experience for patients, visitors, and staff. Objective: To …

Rationale: The austere setting of the intensive care unit (ICU) can suppress expressions of
spirituality. Objectives: To describe how family members and clinicians experience and …

Background Host-associated microbial communities have important roles in tissue
homeostasis and overall health. Severe perturbations can occur within these microbial …

Introduction The objective of this study was to assess the safety and feasibility of in-bed
cycling started within the first 4 days of mechanical ventilation (MV) to inform a future …

Introduction Acute rehabilitation in critically ill patients can improve post-intensive care unit
(post-ICU) physical function. In-bed cycling early in a patient's ICU stay is a promising …