Thyroid hormones influence heart rate, serum lipids, metabolic rate, body weight and
multiple aspects of lipid, carbohydrate, protein and mineral metabolism. Although increased …

An overview of glucocorticoid action is presented including aspects of historic, clinical, and
physiologic interest. Despite the diversity of effects, glucocorticoid hormone action at the …

The initial identification of thyroid hormone receptors (TRs1) was based on binding studies
(Oppenheimer et al., 1972). The TR main ligand is 3, 5, 3!-triiodo-L-thyronine (T3). T3 …

ABSTRACT A method for isolation of large, translationally active RNA species is presented.
The procedure involves homogenization of cells or tissues in 5 m guanidine …

Combinatorial regulation of transcription implies flexible yet precise assembly of multiprotein
regulatory complexes in response to signals. Biochemical and crystallographic analyses …

The crystal structure of the rat aα thyroid hormone receptor ligand-binding domain bound
with a thyroid hormone agonist reveals that ligand is completely buried within the domain as …

Objectives: To determine the relationship between perioperative glucose control and
postoperative nosocomial infection rate in 100 consecutive diabetic patients undergoing …

Glucocorticoids affect the metabolism of most tissues. Frequently, they influence a number of
functions in the same tissue which together produce a pattern of metabolic changes. Many …

The ligand-binding domain of nuclear receptors contains a transcriptional activation function
(AF-2) that mediates hormone-dependent binding of coactivator proteins. Scanning surface …

A randomized study of antiretroviral management based on pla... : AIDS A randomized study of
antiretroviral management based on plasma genotypic antiretroviral resistance testing in …