Background: The evidence base for the diagnosis and management of amyotrophic lateral
sclerosis (ALS) is weak. Objectives: To provide evidence‐based or expert recommendations …

As with other chronic neurologic diseases, many of the problems engendered by the
disease can be managed effectively with a beneficial impact on quality of life and m some …

Amyotrophic lateral sclerosis (known in the UK as motor neuron disease) is a devastating
illness with uncertain pathogenesis. In this Seminar, we review its natural history, clinical …

The fear of “choking to death” is on the mind of most patients suffering from amyotrophic
lateral sclerosis (ALS). So far, however, there have been no systematic surveys concerning …

Non-invasive ventilation (NIV) is an efficient palliative measure for symptoms of chronic
hypoventilation in patients with amyotrophic lateral sclerosis (ALS), and can also lengthen …

To test the safety and efficacy of recombinant human insulin-like growth factor-I (rhIGF-I) in
ALS, 183 patients from eight European centers were randomized to receive double-blind …

Background and purpose The European Association of Palliative Care Taskforce, in
collaboration with the Scientific Panel on Palliative Care in Neurology of the European …

Despite being one of the most devastating diseases known, there is little evidence for
diagnosing and managing patients with amyotrophic lateral sclerosis (ALS). Although …

The coordination and binding of the Mg2+ ion in the nucleotide-binding site of p21 have
been investigated using site-directed mutagenesis, kinetic methods, and phosphorous NMR …

The evidence base for diagnosis and management of ALS is still weak, and curative therapy
is lacking. Nonetheless, early diagnosis and symptomatic therapy can profoundly influence …