We have characterized at the molecular level several polar mutations in four different
cistrons of the his operon of S. typhimurlum. An analysis of the his-specific transcripts …

BACKGROUND: Azacitidine induces responses and prolongs overall survival compared
with conventional care regimens in patients who have high‐risk myelodysplastic syndromes …

Background In the absence of randomized, controlled trial data to support iron chelation
therapy in transfusion‐dependent patients with myelodysplastic syndromes (MDS) …

The polycistronic mRNA of the histidine operon is subject to a processing event that
generates a rather stable transcript encompassing the five distal cistrons. The molecular …

PURPOSE In myelodysplastic syndromes (MDS), severe thrombocytopenia is associated
with poor prognosis. This multicenter trial presents the second-part long-term efficacy and …

Background Venetoclax in combination with hypomethylating agents (HMA) is
revolutionizing the therapy of acute myeloid leukemia (AML). However, evidence on large …

Iron chelation is controversial in higher risk myelodysplastic syndromes (HR‐MDS), outside
the allogeneic transplant setting. We conducted a retrospective, multicentre study in 51 …

Myelodysplastic syndrome patients are subjects of advanced age, vulnerable and frail,
whose outcome is heavily influenced by pre-existing comorbidities worsening the …

Objective The primary objective of this study was to evaluate the health-related quality of life
(HRQOL) in lower-risk, transfusion-dependent patients with myelodysplastic syndromes …

We have cloned and sequenced the genomic regions encompassing the rho genes of
Neisseria gonorrhoeae and Salmonella typhimurium. Rho factor of S. typhimurium has only …