Clinical Note
Baclofen, A Treatment for Chronic Hiccup

https://doi.org/10.1016/S0885-3924(98)00039-6Get rights and content
Under an Elsevier user license
open archive

Abstract

The efficacy of baclofen in the treatment of chronic hiccup is demonstrated in two cases. These cases highlight the present state of knowledge related to hiccup. This discussion focuses on the definition and classification of hiccup, etiologies, postulated theories to explain its function, the few studies performed to date, and non-pharmacologic and pharmacologic treatment. Baclofen appears to be the agent most efficacious in the treatment of chronic hiccup. Its commonest side effect is sedation; insomnia, dizziness, weakness, ataxia, and confusion also can occur. Following regular use, abrupt discontinuation can lead to withdrawal symptoms, such as seizure, and gradual discontinuation is recommended.

Keywords

Hiccup
baclofen
singultus
hiccough

Cited by (0)

Accepted for publication: December 8, 1997.