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A “TNM” classification system for cancer pain: The Edmonton Classification System for Cancer Pain (ECS-CP)

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Abstract

Objective

The purpose of this paper is to provide an overview of the development of a “TNM“ cancer pain classification system for advanced cancer patients, the Edmonton Classification System for Cancer Pain (ECS-CP). Until we have a common international language to discuss cancer pain, understanding differences in clinical and research experience in opioid rotation and use remains problematic. The complexity of the cancer pain experience presents unique challenges for the classification of pain. To date, no universally accepted pain classification measure can accurately predict the complexity of pain management, particularly for patients with cancer pain that is difficult to treat.

Materials and methods

In response to this gap in clinical assessment, the Edmonton Staging System (ESS), a classification system for cancer pain, was developed. Difficulties in definitions and interpretation of some aspects of the ESS restricted acceptance and widespread use.

Result

Construct, inter-rater reliability, and predictive validity evidence have contributed to the development of the ECS-CP. The five features of the ECS-CP—Pain Mechanism, Incident Pain, Psychological Distress, Addictive Behavior and Cognitive Function—have demonstrated value in predicting pain management complexity.

Conclusion

The development of a standardized classification system that is comprehensive, prognostic and simple to use could provide a common language for clinical management and research of cancer pain. An international study to assess the inter-rater reliability and predictive value of the ECS-CP is currently in progress.

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References

  1. Agency for Health Care Policy and Research (1994) Management of cancer pain: adults. Am J Hosp Pharm 51:1643–1656

    Google Scholar 

  2. Arner S, Meyerson BA (1988) Lack of analgesic effect of opioids on neuropathic and idiopathic forms of pain. Pain 33:11–23

    Article  PubMed  CAS  Google Scholar 

  3. Arner S (1998) Pain analysis in prediction of treatment outcome. Acta Anaesth Scand Suppl 113:24–28

    Article  CAS  Google Scholar 

  4. Boisvert M, Cohen SR (1995) Opioid use in advanced malignant disease: why do different centres use vastly different doses? A plea for standardized reporting. J Pain Symptom Manage 10:632–638

    Article  PubMed  CAS  Google Scholar 

  5. Bruera E, Fainsinger R, Spachynski K et al (1995) Clinical efficacy and safety of a novel controlled-release morphine suppository and subcutaneous morphine in cancer pain: a randomized evaluation. J Clin Oncol 13:1520–1527

    PubMed  CAS  Google Scholar 

  6. Bruera E, Macmillan K, Hanson J, MacDonald RN (1989) The Edmonton staging system for cancer pain: preliminary report. Pain 37:203–209

    Article  PubMed  CAS  Google Scholar 

  7. Bruera E, Moyano J, Seifert L, Fainsinger RL et al (1995) The frequency of alcoholism among patients with pain due to terminal cancer. J Pain Symptom Manage 10:599–603

    Article  PubMed  CAS  Google Scholar 

  8. Bruera E, Schoeller T, Wenk R et al (1995) A prospective multicenter assessment of the Edmonton staging system for cancer pain. J Pain Symptom Manage 10:348–355

    Article  PubMed  CAS  Google Scholar 

  9. Bruera E, Sloan P, Mount B et al (1996) A randomized, double-blind, double-dummy, crossover trial comparing the safety and efficacy of oral sustained-release hydromorphone with immediate-release hydromorphone in patients with cancer pain. Canadian Palliative Care Clinical Trials Group. J Clin Oncol 14:1713–1717

    PubMed  CAS  Google Scholar 

  10. Bruera E, Watanabe S, Fainsinger RL et al (1995) Custom-made capsules and suppositories of methadone for patients on high-dose opioids for cancer pain. Pain 62:141–146

    Article  PubMed  CAS  Google Scholar 

  11. Caraceni A, Portenoy RK (1991) An international survey of cancer pain characteristics and syndromes. IASP Task Force on Cancer Pain. International Association for the Study of Pain. Pain 82:263–274

    Article  Google Scholar 

  12. Caraceni A (1996) Clinicopathologic correlates of common cancer pain syndromes. Hematol Oncol Clin North Am 10:57–58

    Article  PubMed  CAS  Google Scholar 

  13. De Stoutz ND, Bruera E, Suarez-Almazor M (1995) Opioid rotation for toxicity reduction in terminal cancer patients. J Pain Symptom Manage 10:378–384

    Article  PubMed  Google Scholar 

  14. Ernst DS, Brasher P, Hagen N et al (1997) A randomized, controlled trial of intravenous clodronate in patients with metastatic bone disease and pain. J Pain Symptom Manage 13:319–326

    Article  PubMed  CAS  Google Scholar 

  15. Fainsinger RL, Lowe S, Nekolaichuk C, Lawlor P (2006) Is pain intensity predictive for complexity of Cancer Pain? Palliat Med 20(3):269

    Google Scholar 

  16. Fainsinger RL, Nekolaichuk CL, Lawlor PG, Neumann CM, Hanson J, Vigano A (2005) A multicentre validation study of the Revised Edmonton Staging System for classifying cancer pain in advanced cancer patients. J Pain Symptom Manage 29:224–237

    Article  PubMed  Google Scholar 

  17. Fainsinger RL, Nekolaichuk CL, Lawlor PG, Neumann CM. Edmonton classification system for cancer pain (ECS-CP). http://www.palliative.org/PC/Clinicalinfo/AssessmentToolsIDX.html

  18. Fainsinger RL, Toro R (1998) Opioids, confusion in opioid rotation. Palliat Med 12:463–464

    Article  PubMed  CAS  Google Scholar 

  19. Foley K (2000) Pain assessment and cancer pain syndromes. In: Doyle D, Hanks G, MacDonald N (eds) Oxford textbook of palliative medicine. Oxford University Press, Oxford, pp 310–331

    Google Scholar 

  20. Hanks G, Portenoy RK, MacDonald N et al (2000) Difficult pain problems. In: Doyle D, Hanks G, MacDonald N (eds) Oxford textbook of palliative medicine. Oxford University Press, Oxford, pp 454–477

    Google Scholar 

  21. Hwang S, Chang V, Kasimis B (2003) Cancer breakthrough pain characteristics and responses to treatment at VA Medical Centre. Pain 101:55–64

    Article  PubMed  Google Scholar 

  22. Hwang SS, Chang VT, Fairclough DL et al (2002) Development of a cancer pain prognostic scale. J Pain Symptom Manage 24(4):366–378

    Article  PubMed  Google Scholar 

  23. Jadad AR, Carroll D, Glynn CJ et al (1992) Morphine responsiveness of chronic pain: double-blind randomized crossover study with patient-controlled analgesia. Lancet 339:1367–1371

    Article  PubMed  CAS  Google Scholar 

  24. Kaiko RF, Wallenstein SL, Rogers AG et al (1982) Narcotics in the elderly. Med Clin North Am 66:1079–1089

    PubMed  CAS  Google Scholar 

  25. Lawlor P, Walker P, Bruera E et al (1997) Severe opioid toxicity and somatization of psychosocial distress in a cancer patient with a background of chemical dependence. J Pain Symptom Manage 13:356–361

    Article  PubMed  CAS  Google Scholar 

  26. Levy MH (1996) Pharmacologic treatment of cancer pain. New Engl J Med 335:1124–1132

    Article  PubMed  CAS  Google Scholar 

  27. Lowe S, Nekolaichuk C, Fainsinger R, Lawlor P (2008) Should the rate of opioid dose escalation be included as a factor in a Cancer Pain Classification System? J Pain Symptom Manage 35(1):51–57

    Article  PubMed  Google Scholar 

  28. Lutfy K, Yoburn BC (1991) The role of opioid receptor density in morphine tolerance. J Pharmacol Exp Ther 256:575–580

    PubMed  CAS  Google Scholar 

  29. Mercadante S, Casuccio A, Pumo S et al (2000) Factors influencing the opioid response in advanced cancer patients with pain followed at home: The effects of age and gender. Support Care in Cancer 8:123–130

    Article  CAS  Google Scholar 

  30. Mercadante S, Fulfaro F, Casuccio A et al (1999) Investigation of an opioid response categorization in advanced cancer patients. J Pain Symptom Manage 18:347–352

    Article  PubMed  CAS  Google Scholar 

  31. Nekolaichuk C, Fainsinger R, Lawlor P (2005) A validation study of a pain classification system for advanced cancer patients using content experts: the Edmonton classification system for cancer pain. Palliat Med 19(6):466–476

    Article  PubMed  Google Scholar 

  32. Otis-Green S, Sherman R, Perez M et al (2002) An integrated psychosocial-spiritual model for cancer pain management. Cancer Pract 10(suppl 1):S58–S64

    Article  PubMed  Google Scholar 

  33. Passik SD, Portenoy RK, Ricketts PL (1998) Substance abuse issues in cancer patients. Part 1: Prevalence and diagnosis.. Oncology 12:517–521

    PubMed  CAS  Google Scholar 

  34. Passik SD, Portenoy RK, Ricketts PL (1998) Substance abuse issues in cancer patients. Part 2: Evaluation and treatment. Clin Tech Small Anim Pract 13:65–69

    Article  Google Scholar 

  35. Passik SD, Theobald DE (2000) Managing addiction in advanced cancer patients: why bother? J Pain Symptom Manage 19:229–234

    Article  PubMed  CAS  Google Scholar 

  36. Piccirillo OJ, Feinstein A (1996) Clinical symptoms and co-morbidity: significance for the prognostic classification of cancer. Cancer 77:834–842

    Article  PubMed  CAS  Google Scholar 

  37. Portenoy RK, Foley KM, Inturrisi CE (1990) The nature of opioid responsiveness and its implications for neuropathic pain: new hypotheses derived from studies of opioid infusions. Pain 43:273–286

    Article  PubMed  CAS  Google Scholar 

  38. Portenoy RK, Lesage P (1999) Management of cancer pain. Lancet 353:1695–1700

    Article  PubMed  CAS  Google Scholar 

  39. Portenoy RK, Payne D, Jacobsen P (1999) Breakthrough pain: characteristics and impact in patients with cancer pain. Pain 81:129–134

    Article  PubMed  CAS  Google Scholar 

  40. Sellers AH (1971) The clinical classification of malignant tumors: the TNM system. CMAJ 105:836–843

    Google Scholar 

  41. South SM, Smith MT (2001) Analgesic tolerance to opioids. Pain 9(5):1–4

    Google Scholar 

  42. Sutton LM, Porter LS, Keefe FJ (2002) Cancer pain at the end of life: a biopsychosocial perspective. Pain 99:5–10

    Article  PubMed  Google Scholar 

  43. Ventafridda V, Tamburini M, Caraceni A, De Conno F, Naldi F (1987) A validation study of the WHO method for cancer pain relief. Cancer 59:850–56

    Article  PubMed  CAS  Google Scholar 

  44. Woolf CJ, Decosterd I (1999) Implications of recent advances in the understanding of pain pathophysiology for the assessment of pain in patients. Pain Suppl 6:S141–S147

    Article  Google Scholar 

  45. Zaza C, Baine N (2002) Cancer pain and psychosocial factors: a critical view of the literature. J Pain Symptom Manage 24:526–542

    Article  PubMed  Google Scholar 

  46. Zech DF, Grond S, Lynch J, Hertel D, Lehmann KA (1995) Validation of the World Health Organization guidelines for cancer pain relief: a 10-year retrospective study. Pain 63:65–76

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

Robin Fainsinger and Cheryl Nekolaichuk are supported by the Canadian Institutes of Health Research through grant support for the CIHR New Emerging Team in Difficult Pain Problems (CIHR PET69772) and an international multicenter validation study of a pain classification system for advanced cancer patients.

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Correspondence to Robin L. Fainsinger.

Additional information

Presented as an invited lecture at the MASCC/ISOO 20th Anniversary International Symposium Supportive Care in Cancer in St. Gallen, June 2007.

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Fainsinger, R.L., Nekolaichuk, C.L. A “TNM” classification system for cancer pain: The Edmonton Classification System for Cancer Pain (ECS-CP). Support Care Cancer 16, 547–555 (2008). https://doi.org/10.1007/s00520-008-0423-3

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