Chest
Clinical InvestigationsLUNG CANCERThe Relationship Between Cigarette Smoking and Quality of Life After Lung Cancer Diagnosis
Section snippets
Study Participants and Data Collection
Since January 1, 1997, patients who have received a pathologic diagnosis of lung cancer have been approached to participate in a prospective cohort study at Mayo Clinic (Rochester, MN), called the Mayo Clinic Lung Cancer Cohort. As of December 31, 2002, 5,445 patients have been enrolled into this cohort with a participation rate of > 95%. Of these patients, 5,198 (95%) have non-small cell lung cancer (NSCLC) or small cell lung cancer (SCLC). All patients have provided written informed consent
Patient Characteristics
Respondents to the first follow-up assessment including the LCSS (1,028 respondents) were more likely to have earlier stage NSCLC compared to the nonrespondents (respondents, 50.7%; nonrespondents, 33.5%) and to be never-smokers (respondents, 17.7%; nonrespondents, 14.7%). Respondents reported a higher percentage of current alcohol use (51.5% vs 45.5%, respectively). Nonrespondents (478 nonrespondents) were younger with 16% of the nonrespondents and 9% of the respondents < 50 years of age at
Discussion
Our hypothesis regarding the relationship between the smoking status of a lung cancer survivor and their QOL was supported by our data. Continued cigarette smoking is related to a lung cancer survivor experiencing a relative deficit in their QOL. Thirty percent of the patients continued to smoke despite being diagnosed with lung cancer. Persistent smokers had worse appetite, fatigue, coughing, dyspnea, symptomatic distress, effect on activities, and overall QOL compared to never-smokers, with
ACKNOWLEDGMENT
We thank Paul Novotny, Brent Williams, and Julian Molina for their helpful suggestions during our research ideas meetings, and Jessica Gardner for her assistance with manuscript production.
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Dr. Garces was supported by National Institutes of Health grant CA–90628 and by the Fraternal Order of the Eagles Cancer Grant Fund. Dr. Yang was supported by National Institutes of Health grants CA–80127 and CA–84354.