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Relationship between opioid treatment and rate of healing in chronic wounds
▸ Shanmugam VK, Couch KS, McNish S, et al. Wound Repair Regen 2016. Published Online First.
A total of 450 people participated in this longitudinal observational study to investigate the relationship between opioids and wound healing. Using fixed-effects models and time-to-event analysis, opioid dose was significantly associated with total wound surface area (p<0.0001); patients with mean opioid dose ≥10 mg were significantly less likely to heal than those with no opioid (HR 0.67 (0.49–0.91), p=0.011) after adjusting for wound size. People who never had opioids healed faster than those who received opioids (p=0.0009). The authors plan to correlate the exposure of opioids and …
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