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Prophylactic cranial irradiation: 5 years on

Abstract

With advances in cancer management, patients are living with the long-term sequelae of both cancer and its treatment. This era of cancer survivorship poses unique challenges to the interdisciplinary cancer team in terms of management and prevention of treatment-related toxicities. This paper describes the case of a 55-year-old patient with neurocognitive disturbance as a result of prophylactic cranial irradiation (PCI). Five years after a diagnosis of small cell lung cancer, she is now an inpatient at a specialist palliative care unit. The current evidence for PCI and for potentially modifiable risk factors for neurocognitive disturbance as a consequence of PCI is explored.

  • Survivorship
  • Small Cell Lung < Cancer
  • Neurocognitive impairment
  • Prophylactic Cranial Irradiation
  • Toxic Leucencephalopathy
  • Received 23 August 2012.
  • Revision received 29 November 2012.
  • Accepted 16 December 2012.

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