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The European Medicines Agency (EMA) has recommended changes to the indications, dose and duration of use of domperidone in adults and children following a review. This follows concerns highlighted in 2012 that domperidone is associated with a small increased risk of serious cardiac undesirable effects. Domperidone is now:
Indicated for nausea and vomiting only, all other uses are unauthorised.
Contraindicated in patients:
Where cardiac conduction is, or could be, impaired;
With underlying cardiac disease, for example, chronic heart failure;
With severe hepatic impairment;
Concurrently receiving drugs known to be CYP3A4 inhibitors and/or cause QT prolongation.
In addition, domperidone:
Should be used at the …
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